N,N-dimethyl-L-prolinamide hydrochloride

N,N-dimethyl-L-prolinamide hydrochloride - Names and Identifiers

Name	2-Pyrrolidinecarboxamide, N,N-dimethyl-, monohydrochloride, (S)-
Synonyms	H-Pro-NMe2 HCl N,N-dimethyl-L-prolinamide hydrochloride L-Proline N,N-dimethylamide hydrochloride (S)-N,N-DiMethyl-2-pyrrolidinecarboxaMide HCl (S)-N,N-Dimethyl-2-pyrrolidinecarboxamide HCl (S)-N,N-Dimethyl-2-pyrrolidinecarboxamidehydrochloride (S)-N,N-Dimethyl-2-pyrrolidinecarboxamide Hydrochloride (S)-N,N-dimethylpyrrolidine-2-carboxamide hydrochloride 2-Pyrrolidinecarboxamide, N,N-dimethyl-, monohydrochloride, (S)-
CAS	149596-90-7

N,N-dimethyl-L-prolinamide hydrochloride - Physico-chemical Properties

Molecular Formula	C7H15ClN2O
Molar Mass	178.6598
Storage Condition	Room Temprature

N,N-dimethyl-L-prolinamide hydrochloride - Introduction

2-Pyrrolidinecarboxamide, N,N-dimethyl-, monohydrochloride, (S)-, also known as DMAP hydrochloride, has the following properties:

1. Nature: DMAP hydrochloride is a white crystalline solid, soluble in water and some organic solvents, such as alcohols and ethers. It is a strong base that reacts with acids to form salts.

2. Use: DMAP hydrochloride is often used as a catalyst in organic synthesis. It can be used as a catalyst for acylation and esterification reactions, accelerate the reaction of esters and alcohols, and improve the reaction rate and product purity. It can also act as an N-oxidant for carbonyl compounds, converting methylene groups in highly electrophilic nucleophiles to formylene groups. In addition, DMAP hydrochloride can also be used in the synthesis of drugs, fine chemicals and amino acid derivatives.

3. Preparation method: The preparation of DMAP hydrochloride is usually obtained by reacting DMAP with hydrochloric acid. A hydrochloric acid solution is formed with hydrochloric acid and a solvent, then DMAP is added to the solution for reaction, filtered and crystallized to obtain the hydrochloride salt.

4. Safety information: the use of DMAP hydrochloride should follow the safe operation procedures of chemical laboratory. It is a corrosive substance that can cause irritation and burns when in contact with the skin or eyes. Wear appropriate protective gloves, glasses and laboratory coats during operation to avoid inhalation of dust or dissolved liquid. In case of accidental contact, rinse immediately with plenty of water and seek medical help.

Last Update：2024-04-09 15:17:52